CooperSurgical has acquired ZyMōt Fertility, a subsidiary of DxNow, Inc. Read the full announcement here.

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One Step Ahead

Introducing the world’s first
single-step culture and transfer medium
containing GM-CSF

SAGE 1-Step™ GM-CSF medium sets a new standard as the first single-step culture and transfer medium containing hyaluronan and a cytokine.

Upgrade your lab with innovation that matters and stand out in the landscape of IVF clinics, all in one step, with SAGE 1-Step GM-CSF.

Now available in Europe 

Improved Outcomes

SAGE 1-Step™ GM-CSF is the only medium that employs a novel combination of hyaluronan and GM-CSF molecules.

SAGE 1-Step GM-CSF, as a combined post-warming culture and transfer medium, increases implantation and live birth rates.

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Optimized Paths to Pregnancy

The role of GM-CSF, a cytokine, is the communication between embryo and endometrium and this intracellular signaling is the key to successful implantation.

The use of GM-CSF can lead to a higher likelihood of live birth, with no reported adverse effects relating to stillbirth, perinatal death, or fetal abnormality.

Clinical Excellence

The inclusion of pro-survival cytokines can reduce embryonic stress by creating a more physiological in vitro environment.

SAGE 1-Step GM-CSF is designed with an optimized combination of nutrients, amino acids, antioxidants, and macromolecules to help successfully support embryo metabolism and maximize embryo development from zygote to blastocyst stage.

Patient Attraction and Retention

Offer your patients an additional treatment option with SAGE 1-Step GM-CSF medium to allow for a more personalized treatment for advanced maternal age patients and patients with one or more failed attempts.

GM-CSF: The Great Communicator

Research shows that GM-CSF’s signaling in vivo plays a crucial role in facilitating successful implantation, embryo development, promoting enhanced immune response1 and protecting the embryo from cell stress.2

Download the
SAGE 1-STEPTM GM-CSF Media Product Brochure

Download Now
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References

  1. Mor, G., Aldo, P. & Alvero, A. The unique immunological and microbial aspects of pregnancy. Nat Rev Immunol 17, 469–482 (2017). https://doi.org/10.1038/nri.2017.64
  2. Robertson, S.A. (2018) GM-CSF in IVF Embryo Culture. ART Scientific Edition 4: 1-4.

To learn more, contact your local CooperSurgical representative or complete the form below:

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